Insular volume abnormalities associated with different transition probabilities to psychosis

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Insular volume abnormalities associated with different transition probabilities to psychosis

BACKGROUND Although individuals vulnerable to psychosis show brain volumetric abnormalities, structural alterations underlying different probabilities for later transition are unknown. The present study addresses this issue by means of voxel-based morphometry (VBM). METHOD We investigated grey matter volume (GMV) abnormalities by comparing four neuroleptic-free groups: individuals with first ...

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CONTEXT Whether psychoses associated with schizophrenia and affective disorder represent manifestations of different disorders or the same disorder is an important but unresolved question in psychiatry. Results of previous volumetric magnetic resonance imaging investigations indicate that gray matter volume reductions in neocortical regions may be specific to schizophrenia. OBJECTIVE To simul...

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Patients with psychosis display structural brain abnormalities in multiple brain regions. The disorder is characterized by a putative prodromal period called ultra-high-risk (UHR) status, which precedes the onset of full-blown psychotic symptoms. Recent studies on psychosis have focused on this period. Neuroimaging studies of UHR individuals for psychosis have revealed that the structural brain...

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ژورنال

عنوان ژورنال: Psychological Medicine

سال: 2011

ISSN: 0033-2917,1469-8978

DOI: 10.1017/s0033291711002716